Monosodium Glutamate

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“I’ve been treating eating disorders (ED’s) and obesity for nearly 25 years and have always had good outcomes. My rate of success improved dramatically, however, when I discovered the critical role that processed food plays in causing as well as in preventing recovery from Anorexia, Bulimia, Bulimarexia, (a combination of the two) Binge Eating Disorder (BED,) Emotional Eating and Obesity. To this end, I find it of great importance to provide both my patients and readers with relevant nutrition information to aid in their recovery. You can view all my Nutrition, Fitness, and Health articles here.


Monosodium Glutamate, a food ingredient, was invented in 1908 in Japan, by Kikunae Ikeda. A year later, with a partner, he formed a company, Ajinomoto, to produce the product. The food additive did not appear in the United States to any degree until the late 1940s, following the Second World War. During the war, it had been noted that Japanese soldiers’ rations tasted better than the rations used by our soldiers. The difference was believed to be “monosodium glutamate.” Today, “monosodium glutamate” or its reactive component, “processed free glutamic acid,” is found in almost all of the processed foods that are manufactured in the United States.


In 1957, Lucas and Newhouse found that normal neonatal mice suffered acute degenerative lesions in the inner retina when “monosodium glutamate” was administered by feeding tube. In 1968, during a replication of this study at Washington University Medical School, St., Louis, Missouri, Dr. John W. Olney noted that, some of the mice had become grotesquely obese. He decided to sacrifice some of the mice to confirm his belief that lesions would be found in the hypothalamus region of the brain. Not only was his suspicion confirmed, but further testing indicated that there were also other neuroendocrine effects from the “monosodium glutamate.” His findings were published in 1969. Dr. Olney, a National Academy of Science scientist who is credited for the voluntary removal of MSG from baby food in the 1970s, continues to publish research on the toxicity of glutamic acid, often using “monosodium glutamate.”

In 1968, the New England Journal of Medicine published a Letter to the Editor in which Ho Man Kwok, MD, asked for help in determining why he and his friends suffered reactions shortly after eating in some Chinese restaurants, though he never experienced such reactions when he lived in China. The journal titled the letter “Chinese Restaurant Syndrome,” and researchers from around the country wrote the journal to suggest that Dr. Kwok and his friends’ problem was intolerance to MSG. One letter indicated that 30% of the population reacted to MSG.

In 1969, concerned with the bad reports regarding “monosodium glutamate,” the glutamate industry formed a nonprofit organization to defend the safety of MSG, the International Glutamate Technical Committee. Later, in 1977, they increased their efforts with the development of a nonprofit subsidiary, The Glutamate Association, primarily operating as a public relations arm of the glutamate industry. In about 1990, the glutamate industry turned to the International Food Information Council (IFIC), another nonprofit industry-funded organization, to be their spokesman and to promote the safety of MSG along with the other products that they represent.


The literature is clear in demonstrating that MSG is toxic to humans and that over 25% of the population suffer adverse reactions from MSG. In the opinion of this writer, the subject is only controversial because of the input of the three organizations mentioned above and because of research they have funded to discredit findings of others and to tell the story that the glutamate industry wants told, research that is flawed to the point of being worthless.

“Monosodium glutamate” is approximately 78% processed free glutamic acid and 22% sodium (salt) and moisture, with about 1% contaminants. It is the processed free glutamic acid that causes people to suffer adverse reactions, and, unfortunately, there are over 40 food ingredients other than “monosodium glutamate” that contain processed free glutamic acid in varying amounts. Consequently, consumers refer to all processed free glutamic acid as MSG, regardless of the name of the ingredient.

People differ in their tolerances to MSG, but typically always suffer similar reactions each time they ingest amounts of MSG that exceed their tolerances for the substance. Reactions experienced vary dramatically, as if MSG finds the weak link in the body. Typically, people will suffer reactions at approximately the same time each time they ingest amounts of MSG that exceed their tolerance levels. However, that time lapse can vary among people from immediately following ingestion of MSG up to 48 hours following ingestion. Use of alcohol or exercise prior to, during or following an MSG-containing meal will exacerbate an MSG reaction in many people. MSG-sensitive people will typically suffer similar reactions to aspartame.

Neuroscientists believe that the young and the elderly are most at risk from MSG. In the young, the blood-brain barrier is not fully developed, exposing the brain to increased levels of MSG that has entered the bloodstream. The elderly are at increased risk because the blood-brain barrier can be damaged by aging, by disease processes, or by injury, including hypertension, diabetes, hypoglycemia, and stroke. Throughout life, the blood-brain barrier is “leaky” at best.

MSG has now been implicated in a number of the neurodegenerative diseases, including ALS (Lou Gehrig’s disease), Parkinson’s disease, Alzheimer’s disease, multiple sclerosis and Huntington’s disease.

In general, the natural glutamic acid found in food does not cause problems, but the synthetic free glutamic acid formed during industrial processing is a toxin. In addition, when MSG is formed using hydrochloric acid the final product includes carcinogens.


A Canadian Study conducted, leaves no room for doubt that ingredients that contain processed free glutamic acid (MSG) and free aspartic acid — known neurotoxins— are used in baby formula. The fact that neurotoxins are present in baby formula is of particular concern since the blood brain barrier is not fully developed in infants, allowing neurotoxins to be more accessible to the brain than is the case in healthy adults.

In studies using experimental animals, neuroscientists have found that glutamic acid and aspartic acid load on the same receptors in the brain, cause identical brain lesions and neuroendocrine disorders, and act in an addictive fashion.

You will note that the level of neurotoxins found in the hypoallergenic formula was far greater than the level of neurotoxins found in the other formulas. In reviewing the literature on hypoallergenic formulas, we have found short-term studies that concluded that hypoallergenic formulas are safe because babies tolerated them and gained weight. However, we have not seen any long-term studies on the safety of hypoallergenic formulas. We believe that well designed long term studies would demonstrate that infants raised on hypoallergenic formulas, as compared to infants who are breastfed or fed on non-hypoallergenic formulas, will exhibit more learning disabilities at school age, and/or more endocrine disorders, such as obesity and reproductive disorders, later in life. Long-term studies on the effects of hypoallergenic formulas need to be done.

To put these figures in perspective, consider that in an FDA-sponsored study dated July, 1992 entitled “Safety of Amino Acids Used in Dietary Supplements,” the Federation of American Societies for Experimental Biology concluded, in part, that “…it is prudent to avoid the use of dietary supplements of L-glutamic acid by pregnant women, infants, and children. . . and. . . by women of childbearing age and individuals with affective disorders.” (MSG is called glutamic acid or L-glutamic acid when used in supplements.)

During the 1960s, the food ingredient “monosodium glutamate” was routinely added to baby foods. The industry “voluntarily” ceased the practice after Congressional hearings in which concerned researchers warned of serious adverse effects. However, for some years following the elimination of “monosodium glutamate,” hydrolyzed proteins were used in place of “monosodium glutamate.” Hydrolyzed proteins always contain MSG.

Many consumers now know to avoid baby foods with hydrolyzed proteins. Yet how many parents realize that MSG lurks in every bottle of formula given to their infants? Babies on hypoallergenic formulas receive about 1 gram of total neurotoxins per day, a level at which many MSG-sensitive individuals experience adverse reactions.

Our advice to you is to do your best to eliminate MSG from your diet. You will feel better. That means avoiding all processed foods. Our advice to investigators of school violence is to investigate the effects of excitotoxins in children’s diets. There are high levels of MSG in soy products and seasoning mixes used in school lunch programs, fast foods and snack foods.

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Medical Advice Disclaimer: The information included on this site is for educational purposes only. It is not intended nor implied to be a substitute for professional medical advice. The reader should always consult his or her healthcare provider to determine the appropriateness of the information for their own situation or if they have any questions regarding a medical condition or treatment plan. Reading the information on this website does not create a physician-patient relationship.

© 2012, Dr J Renae Norton. This information is intellectual property of Dr J Renae Norton. Reproduction and distribution for educational purposes is permissible.

Please credit ‘© 2012, Dr J Renae Norton. //’

This article was modified from:

World Health Center: Natural Products and Healing – MONOSODIUM GLUTAMATE: POISON THE BODY TO BETTER THE TASTE!

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